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    Home » Dinner Recipes

    Four Cheese Manicotti

    BY: Ben Rayl UPDATED: February 12, 2025 17 Comments

    RecipeVideoPrintComments
    5 from 13 votes

    This cheesy stuffed four cheese manicotti recipe is so delicious and easy to make. Baked manicotti is an Italian dish with creamy spinach stuffed in large pasta shells, marinara sauce, and cheese. It's perfect for feeding a large crowd and is great for a comforting winter meal on a budget!

    Four Cheese Manicotti - Featured

    🌟 Why this recipe works

    Manicotti is easy to make and can be stuffed with various fillings. This particular recipe uses a creamy spinach cheese filling, which pairs perfectly with the marinara sauce and four types of cheese.

    The stuffed manicotti shells are then baked in the oven until golden brown, and the cheese is bubbly, resulting in a comforting and delicious meal that the whole family will love!

    You can make a fun recipe at home with the kids to help you stuff the large shells with the spinach and cheese mixture to speed up the prep work.

    Although it takes 1 hour baked in the oven for the pasta shells to become tender, it is worth the wait when you see the delicious cheesy mixture oozing from them in the tomato sauce covered with mozzarella cheese,

    Homemade manicotti is perfect for a big family meal on a budget and great for any occasion with simple ingredients and essential cookware required. I highly recommend to serve this dish with my easy tiramisu as a dessert!

    🍽 Key Ingredients

    This utterly cheesy recipe requires four types of cheese for the mixture and fresh spinach leaves to stuff inside the manicotti Italian pasta shells.

    Manicotti ingredients

    Manicotti shells: Look for large shells that are easy to stuff.

    Spinach: Use fresh spinach leaves to combine with the cheese mixture.

    Cheeses: Parmesan cheese, ricotta cheese, cottage cheese, and mozzarella make up this 4 cheese pasta recipe.

    Tomato sauce: You can use store-bought marinara sauce or homemade marinara sauce.

    Garlic & onion: Thinly sliced cloves of garlic and sliced rounds add flavor to the cheese and spinach mixture.

    Substitutes

    Spinach

    You can use frozen, but you'll need to thaw and drain all the juices from it first, which is tedious and time-consuming.

    Manicotti

    If you don't have manicotti shells at your local grocery store, you can use cannelloni shells as an equal replacement for stuffing with the cheese filling.

    🔪 How to make

    This stuffed four cheese manicotti with meat sauce is easy to make and super delicious, which will impress your guests. The pasta shells are stuffed with creamy spinach and cheese filling and baked in the oven until golden brown.

    Preparations

    Step 1

    Peel the onion and cut thin circles using a sharp knife.

    Step 2

    Finely chop the garlic.

    Cooking instructions

    Step 3

    Preheat oven to 350 degrees Fahrenheit (175 degrees Celsius) and grease a large casserole dish.

    Step 4

    In a large pot, boil the manicotti pasta shells for about 2 minutes less than the package instructs. (Add some oil to the water so that they don't stick together).

    Step 5

    Rinse and drain the al dente manicotti shells under cold water and set them aside.

    Drained Manicotti Pasta

    Step 6

    Heat the butter in a large skillet over medium heat, and add the onion and the garlic for 3 to 4 minutes, until the onion is soft, then transfer to a bowl.

    Butter, Onion and Garlic in Skillet

    Step 7

    Drain the liquid from the cottage cheese and combine ricotta cheese, parmesan cheese, and 1 cup of mozzarella cheese in a bowl.

    Combined Cheeses in Bowl

    Step 8

    Stir in the beaten eggs, the spinach leaves, and the onion mixture until well combined. Season with salt and pepper.

    With Eggs, Spinach and Onion Mixture

    Step 9

    Spread about 1 cup of marinara sauce evenly on the bottom of the casserole dish.

    Marinara Sauce on Casserole

    Step 10

    Stuff the manicotti shells full of cheese filling, and arrange them on top of the sauce. 

    Manicotti with Cheese Filling

    Step 11

    Pour the remaining sauce over the shells and use a spoon to move them around a bit so that the sauce gets between them. Then sprinkle the rest of the mozzarella cheese on top and cover with foil.

    Ready to Bake Manicotti Dish

    Step 12

    Bake in the oven for about 45 minutes, then remove the foil and bake for 15 more until the cheese begins to turn golden brown and the sauce starts to bubble.

    Removed Foil and Browned Cheese

    Step 13

    Serve with fresh basil leaves, remaining parmesan cheese, and a dollop of sour cream.

    Garnished with Basil and Parmesan

    💭 Cooking tips

    Fill the shells

    An easy way to fill the shells is by pouring the mixture into a ziplock bag and cutting the corner to pipe it directly into the shell hole. Alternatively, you can spoon it into the manicotti.

    Thick mixture

    If the cheese mixture is too thick, add a little milk or water to thin it out.

    Four Cheese Manicotti3

    📖 Variations

    There are many ways that you can change up this spinach and cheese manicotti recipe to suit your taste or dietary needs. Here are some ideas:

    Chicken and spinach manicotti

    Four cheese spinach manicotti variation is super easy to make and really tasty.

    The chicken and spinach go well together, and the cheese adds a delicious creaminess to the dish. Mix one cup of shredded chicken into the mixture.

    Seafood manicotti

    This variation is perfect for those who love seafood. The seafood gives the dish a nice sweetness and pairs well with the cheese and spinach. Add 1 cup of cooked prawns into the cheese and spinach mixture.

    Manicotti recipe with meat

    For full-on meat manicotti noodles, add 1 cup of cooked Italian sausage or ground beef mixed with a teaspoon of Italian seasoning.

    Four Cheese Manicotti2

    🥗 What to serve with Four Cheese Manicotti

    There are a few things you can serve with this delicious homemade manicotti pasta dish to make it a complete meal. A simple salad is always a good choice, or you could go for something heartier like roasted potatoes, a tasty soup, or garlic bread.

    Salad

    Spinach, chicken, bacon, and brie salad: This salad is perfect for those who love chicken and bacon. The chicken and bacon go well together, and the brie cheese adds a delicious creaminess to the salad.

    Potatoes

    Italian fries with rosemary and garlic: This quick and easy recipe is great for dipping into the delicious sauce from the four cheese manicotti - and the flavor of rosemary and garlic gives the fries a nice flavor with a crispy texture.

    Soup

    Roasted tomato soup: This soup is full of flavor and ever so creamy. It's rich in tomato, herbs, garlic, and spices to warm you up on a winter's evening and goes well with the baked manicotti.

    🙋 Frequently Asked Questions

    Can you prepare manicotti in advance?

    Yes, you can prepare the manicotti ahead of time and bake it when you're ready to eat. Simply follow the recipe up until the point of baking, then cover and refrigerate the dish. When you're ready to bake, remove it from the fridge, and preheat the oven before baking.

    Do you have to pre-cook manicotti shells?

    No, you don't have to pre-cook the manicotti shells before stuffing them. Simply stuff them with the cheese and spinach mixture and bake as directed.

    Manicotti Serving

    🧊 Storage and ♨️ reheating

    This baked manicotti recipe is ideal for eating the following day once the cheese flavors have infused into the pasta shells and can be eaten cold or reheated.

    Fridge - Store in an airtight container and consume within 3-4 days

    Freezer - Transfer the leftover manicotti to an airtight container and freeze for up to 2 months.

    Reheating - Place leftover manicotti in a baking dish, cover with foil, and heat at 350 degrees until warmed through. Alternatively, you can microwave individual pieces for 1-2 minutes.

    🍳 Related Recipes

    If you like this manicotti recipe, you should try one of these delicious comfort food pasta recipes.

    • Three cheese lasagna
      Three-Cheese Lasagna (Easy & Delicious)
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    • Beef Stroganoff featured
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    For more Italian recipes inspiration I recommend you to try my bruschetta with mozzarella, pizza monkey bread, and my stuffed rigatoni!

    👪 Serving size

    You can expect to get 6 generous servings of baked manicotti using this recipe, or you could easily double or triple the quantity by layering more stuffed shells on top with more marinara sauce and mozzarella cheese.

    This four cheese manicotti recipe is a delicious and easy-to-make dish that is perfect for any occasion. The cheesy manicotti can be made ahead of time and frozen for later, or you can enjoy it fresh out of the oven.

    🎥 Watch how to make it

    📋 Recipe

    Four Cheese Manicotti - Featured

    Four Cheese Manicotti

    This cheesy stuffed manicotti recipe is so delicious and easy to make. Baked manicotti is an Italian dish with creamy spinach stuffed in large pasta shells, marinara sauce, and cheese. It's perfect for feeding a large crowd and is great for a comforting winter meal on a budget!
    5 from 13 votes
    Print Pin Rate Save Saved! Share
    Course: Dinner, Lunch
    Cuisine: Italian
    Prep Time: 30 minutes minutes
    Cook Time: 1 hour hour
    Total Time: 1 hour hour 30 minutes minutes
    Servings: 6 Servings
    Calories: 491kcal
    Author: Ben Rayl

    Ingredients
     

    • 1 box manicotti - about 12 shells
    • 2 tablespoon butter
    • 1 medium onion - sliced in rounds
    • 3 cloves garlic - thinly sliced
    • 16 oz cottage cheese
    • 8 oz ricotta cheese
    • 2 cups mozzarella - separated
    • 3 cups tomato sauce - Italian
    • 2 eggs - beaten
    • 3 cups spinach - chopped, packed
    • ½ cup parmesan - freshly grated plus more for garnish
    • salt and pepper - to taste

    Instructions

    • Preheat the oven to 350 F (175 C) and grease a large casserole dish.
    • In a large pot, boil the manicotti (add some oil to the water so they don't stick together) for about 2 minutes less than package instructs, then run under cold water before draining and set aside.
    • Heat the butter in a large skillet over medium heat then add the onion and cook for about two minutes.  Add the garlic and cook for 3 minutes more, until the onion is soft then remove from heat and set aside.
    • Put the cottage cheese (drain any excess liquid), ricotta, parmesan, 1 cup of the mozzarella in a large bowl and mix well.
    • Stir in the beaten eggs, the spinach and onion until well combined and season with salt and pepper.
    • Spread about 1 cup of the tomato sauce evenly on the bottom of the casserole dish.
    • Stuff the manicotti shells full with cheese and spinach mixture and arrange on top of the sauce.  (you can spoon the filling into the shells, or put it in a ziplock bag, then cut the corner and pipe the cheese mixture in)
    • Pour the remaining 2 cups of sauce over the shells and use a spoon to move them around a bit so the sauce gets between the manicotti, then sprinkle the rest of the mozzarella cheese on top and cover with foil.
    • Bake in the oven for about  45 minutes, then remove foil and bake for 15 more minutes, until the cheese is beginning to turn golden and the sauce is bubbling.

    Video

    Notes

    Fill the shells
    An easy way to fill the shells is by pouring the mixture into a ziplock bag and cutting the corner to pipe it directly into the shell hole. Alternatively, you can spoon it into the manicotti.
    Thick mixture
    If the cheese mixture is too thick, add a little milk or water to thin it out.

    Nutrition

    Calories: 491kcal | Carbohydrates: 43g | Protein: 33g | Fat: 21g | Saturated Fat: 11g | Trans Fat: 1g | Cholesterol: 122mg | Sodium: 1358mg | Potassium: 787mg | Fiber: 4g | Sugar: 10g | Vitamin A: 2616IU | Vitamin C: 15mg | Calcium: 488mg | Iron: 3mg

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    Reader Interactions

    Comments

      5 from 13 votes (2 ratings without comment)

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      Recipe Rating




    1. Anonymous

      April 22, 2013 at 12:30 am

      If you're not a vegan, a pound or so of burger mixed in would really be awesome!

      Reply
    2. jonissa jones

      August 30, 2013 at 2:00 am

      So,i made this tonight, freaking delish!!!

      Reply
    3. New Ideas | Four cheese (and spinach) manicotti

      November 06, 2013 at 5:48 am

      […] For full recipe, directions and to print go to: https://comfortablefood.com/four-cheese-manicotti/ […]

      Reply
    4. Teresita Nunez Ortiz

      March 05, 2015 at 10:01 am

      I Wonder if you can prep ahead and leave in fridge, anyone has tried?

      Reply
    5. Liz

      November 08, 2018 at 7:04 am

      5 stars
      My daughter is super picky and this was a recipe the whole family loved! I'll be making it again and again!

      Reply
    6. Lori

      November 08, 2018 at 7:49 am

      5 stars
      This is a family favorite!

      Reply
    7. Melissa Sperka

      November 08, 2018 at 8:31 am

      5 stars
      My go to recipe for meatless Monday!!

      Reply
    8. Trish Rosenquist

      November 08, 2018 at 7:01 pm

      5 stars
      My favorite kind of comfort food - yum!

      Reply
    9. Barbara Schieving

      November 08, 2018 at 7:31 pm

      5 stars
      We love all that cheesy deliciousness too.

      Reply
    10. Brenda

      November 08, 2018 at 8:20 pm

      5 stars
      I love new ways to sneak spinach into our family meals! 🙂

      Reply
    11. Joanne

      November 08, 2018 at 8:34 pm

      5 stars
      This is perfect. All the right proportions of ingredients!

      Reply
    12. Ashley @ Wishes & Dishes

      November 08, 2018 at 9:57 pm

      5 stars
      This is amazing!! All that cheese!

      Reply
    13. Toni | Boulder Locavore

      November 09, 2018 at 3:14 am

      5 stars
      My family really enjoyed this for dinner!

      Reply
    14. Sandy

      November 09, 2018 at 7:43 am

      5 stars
      Such a great comfort dish!

      Reply
    15. Stephanie Manley

      November 10, 2018 at 7:16 am

      5 stars
      I love the flavor combination in this manicotti, so delicious!

      Reply

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    Chef Ben Rayl

    Hi, I'm Ben!

    I believe comfort food unites us, and I want to inspire you to cook at home with everyday ingredients. It is easier and takes less time than you think, costs less than eating out, and tastes a million times better.Read More

    Feel free to share our recipes on your blog using a photo and link back to the original recipe.

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