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    Home » Casserole Recipes

    Chicken Tetrazzini Casserole

    BY: Ben Rayl UPDATED: February 12, 2025 26 Comments

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    4.72 from 7 votes

    This chicken tetrazzini casserole recipe is Italian-American food at its best. It's rich, creamy, and perfectly hearty - this casserole makes a wonderful dinner any time. This recipe can be very versatile, and it's easy to modify, so have fun with it.

    Chicken Tetrazzini Casserole with  creamy spagheti noodles

    I have a lot of excellent oven-baked chicken casseroles. But right now I just want to shine a light on my baked chicken cordon bleu, baked chicken legs and easy chicken broccoli casserole, which are both fantastic and super easy to make.

    Contents
    • 🐓 Easy Chicken Tetrazzini
    • 🍽 Ingredient notes
    • 🔪 How to make Chicken Tetrazzini
    • 💭 Tips for the perfect Chicken Tetrazzini
    • 🙋 Can I make this casserole dish ahead of time?
    • 🧊 Storing and ♨️ Reheating
    • 🥗 What to serve with Chicken Tetrazzini
    • 🍳 Related Comfort Food Recipes
    • 👪 Serving size
    • 🎥 Video
    • 📋 Recipe
    • 💬 Comments

    🐓 Easy Chicken Tetrazzini

    If you're from the South, then you know a family union is not complete without creamy casseroles and comforting pasta dishes with lots and lots of cheese. This chicken pasta casserole brings back the memories of our family reunions over the years. The fleeting but precious days full of laughter and delicious spread of food.

    My mum's chicken tetrazzini was a showstopper. Each bite, and you'll feel the love. This creamy, buttery delight was always a hit with everyone in the family.

    I've made this casserole dish countless times, so I want to share this hard to resist recipe today. If you're a fan of bold flavors, then you'll love this pasta bake recipe.

    What's more, it's so easy to make! Don't let the tetrazzini name fool you into believing it's something complicated or fancy. A super chef named it after an Italian opera star - that's it! Try it, and I promise you won't be disappointed. If you have a busy week I recommend you to try my 20 minute penne carbonara recipe.

    The bonus of this recipe? It's freezer-friendly, and you can make it well in advance. Similar to my mouth-watering texas chicken spaguetti recipe.

    🍽 Ingredient notes

    Fresh mushrooms are a nice touch and you can easily incorporate cream of mushroom soup or cream of chicken soup for an amazing recipe. Just cut back on chicken broth!

    I prefer using half and half because it has lower fat content than whipping cream or heavy cream. The trade-off is you get a thinner consistency, but it still packs a creamy mouthfeel and tangy flavor.

    Substitutes

    Pasta

    I used regular spaghetti for this tetrazzini chicken recipe because it holds up well in creamy sauces, but feel free to use any pasta. I've seen people using linguine, vermicelli, and even fettuccine. If you're intolerant to gluten or trying to cut out refined carbs. In that case, you can use alternatives such as chickpea pasta, shirataki noodles, zucchini noodles, and the likes. In short, just use your favorite pasta and see how it goes.

    Chicken

    The best thing about chicken is how versatile it is. So yes, you can substitute chicken breasts for thighs or tenderloin. If you're feeling uninspired or short on time and got some leftover chicken after a roast or from a rotisserie chicken you had bought at the store, feel free to use it up. You can even swap chicken for turkey.

    Veggies

    You can always add more veggies to your chicken tetrazzini. It's an incredible way to add a dose of nutrients to your casserole. You can vegetize your cream of chicken with peas, red bell pepper, celery, asparagus, or any other veggie of your liking!

    White wine

    If the idea of adding wine doesn't sound appealing to you or you don't have it on hand, just leave it out. Use more chicken broth instead for a richer, deeper flavor.

    🔪 How to make Chicken Tetrazzini

    Start by preheating the oven to 425 degrees Fahrenheit (218 degrees Celsius) and greasing your casserole dish.

    Step 1

    In a medium-sized skillet, heat oil over medium-high heat. You can use olive oil if you wish. Meanwhile, season the skinless chicken breasts with generous amounts of salt and pepper on both sides. You can use a spice rub if you have it on hand to add extra flavor.

     four chicken breast cooking in cast iron skillet

    Step 2

    Once the oil is hot, place your chicken breasts in the pan and allow them to cook for about 4-5 minutes without moving them. This will give it a nice crust. Flip the chicken pieces over and cook for another 3-4 minutes. Remove from heat, place on a plate, and allow it to sit for a few minutes before dicing.

    In the meantime, bring water to a boil. Add pasta and cook according to package instructions, but 1 minute less. Drain in a colander and let it sit.

     four chicken breast cooking in large skillet

    Step 3

    In the same skillet, you cooked the breasts with, melt 2 tablespoons of butter over medium heat. Add your onions, green pepper and cook for about 4 minutes or until they start to soften.

     onions, green pepper cooking in large skillet

    Step 4

    Increase the heat to medium-high, then add your mushrooms. Cook for about 5 minutes or until golden brown.

    mushrooms and greens cooking in a pan

    Step 5

    Melt the remaining butter in a saucepan over medium-low heat. Add flour and stir until smooth. Slowly add your broth and the half- half, constantly stirring with a wooden spoon or spatula. Increase the heat to medium, then stir for 10 minutes or until the sauce is thick.

    making the cream sauce

    Step 6

    Add white wine, the mushroom mixture, and stir. Toss the cooked chicken breasts in the sauce until completely coated.

    chicken breasts in the sauce  completely coated.

    Step 7

    Pour your spaghetti into the greased baking dish, then the creamy sauce over the top. Tilt the dish to spread evenly.

    spaghetti into  baking dish, with chicken and creamy sauce

    Step 8

    Sprinkle some parmesan cheese over the top, cover, and bake for about 20 minutes or until hot and bubbly.

    I like to garnish with paprika or fresh parsley before serving to heighten the flavor.

    chicken tetrazzini casserole serving

    That how easy it is to make chicken tetrazzini!

    Pro tip: if your casserole dish is filled to the brim, place a cookie sheet or liner in the oven to catch any spills and avoid hard-to-clean messes.

    Any Cheese Goes!

    While the traditional way calls for parmesan cheese, you're welcome to use any cheese you like. For great results, I'd recommend fontina, provolone, romano, and mozzarella cheese. These cheeses melt beautifully, are mildly flavored, and will definitely up your cream sauce game.

    💭 Tips for the perfect Chicken Tetrazzini

    • Want to add more spices or herbs? Do it. Don't like mushrooms? by all means, exclude them. Want it a bit more buttery and cheesy? Just add more!
    • Want to add more spices or herbs? Do it. Don't like mushrooms? by all means, exclude them. Want it a bit more buttery and cheesy? Just add more!
    • When it comes to white wine, opt for a light-bodied dry white. I prefer oaked chenin blanc, chardonnay, sauvignon blanc or viognier.
    • Always use low-sodium chicken broth. If possible, make your own homemade broth.
    • Undercook the pasta to avoid a mushy baked mess.
    • The sauce shouldn't be too thick or thin. Add more broth or wine to maintain a nice consistency.

    🙋 Can I make this casserole dish ahead of time?

    Absolutely! This chicken tetrazzini recipe comes together in less than an hour, but you can still make it ahead of time if you want to. Simply follow the cooking instructions, then refrigerate without baking or topping with cheese.

    Cover the dish tightly with either aluminum foil or plastic wrap. You can leave it in the fridge for up to 24 hours. When ready, proceed with toppings and bake according to the recipe instructions.

    🧊 Storing and ♨️ Reheating

    Chicken tetrazzini leftovers can be refrigerated or frozen. If stored in an airtight container or freezer bag, it can last up to 4 days in the fridge.

    When frozen, it can stay for up to 2 months.

    When ready to serve, thaw in the fridge overnight. To reheat, preheat oven to 350, cover with foil, then bake for 10-15 minutes or until heated through. You can also reheat it on the stove or microwave.

    🥗 What to serve with Chicken Tetrazzini

    To be honest, chicken tetrazzini is absolutely fantastic on its own. But you can add side dishes to make the meal more appealing. Also, there's nothing wrong with adding extra flavors to the plate, right?

    Here are some of my favorites:

    Cheesy Garlic Knots - So cheesy, garlicky, and delicious, making it a perfect side for this recipe.

    Parma Sticks - will add a crispy twist to your creamy chicken tetrazzini.

    Steamed Vegetables - you can never go wrong with steamed vegetables drizzled in garlic oil sauce. This combination is heavenly.

    Goat Cheese Salad - this sweet and savory salad adds an interesting, fun twist to this casserole. You'll love it!

    🍳 Related Comfort Food Recipes

    Try one of these fantastic comfort food recipes for your next meal. For more Italian recipes inspiration I recommend you to try my bruschetta with mozzarella, pizza monkey bread, four cheese manicotti and my stuffed rigatoni!

    • Three cheese lasagna
      Three-Cheese Lasagna (Easy & Delicious)
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    Looking for a delicious and easy side dish casserole? Try my 30 minutes green bean casserole with homemade crispy onions.

    chicken tetrazzini casserole ready to serve

    👪 Serving size

    So if you're looking for a crowd-pleasing chicken dinner idea for a laid-back weekend or even a busy weeknight, try this scrumptious tetrazzini chicken recipe that serves 6 people.

    If you are a pasta fan you must try my delicious chicken and shrimp carbonara olive garden copycat recipe. Super easy to make and it takes even better than the restaurant!

    🎥 Video

    This hearty and perfectly satisfying chicken tetrazzini is a true definition of classic comfort food. The chicken's deliciousness combined with pasta, mushrooms in a cheesy, buttery, creamy sauce will have your mouth watering for more. Everyone in your family will love this -even the pickiest of eaters!

    Check out my fantastic four cheese stuffed manicotti recipe that you can have it on your table in less than 1 hour!

    Love this recipe? Please leave a 5-star 🌟rating in the recipe card below and/or a review in the comments section further down the page.

    Try one of my comfort dinner recipes for your next family meal! And if you have any questions, I'm here to help!

    📋 Recipe

    Recipe for a rich and creamy chicken casserole

    Chicken Tetrazzini Casserole

    This chicken tetrazzini casserole recipe is Italian-American food at its best. It's rich, creamy, and perfectly hearty - this casserole makes a wonderful dinner any time. This recipe can be very versatile, and it's easy to modify, so have fun with it.
    4.72 from 7 votes
    Print Pin Rate Save Saved! Share
    Course: Casserole, Dinner, Main Dish, Pasta
    Cuisine: American, Italian
    Prep Time: 30 minutes minutes
    Cook Time: 20 minutes minutes
    Total Time: 50 minutes minutes
    Servings: 6 servings
    Calories: 561kcal
    Author: Ben Rayl

    Ingredients
     

    • 2 tablespoons vegetable oil
    • 2 chicken breasts
    • to taste salt and pepper
    • 1 16 ounces package spaghetti
    • 6 tablespoons butter
    • ½ medium onion - chopped
    • 1 green pepper - finely diced
    • 1 cup mushrooms - sliced
    • ¼ cup all purpose flour
    • 1 cup half and half
    • 2 cups chicken broth
    • ¼ cup white wine
    • ½ cup parmesan cheese - shredded
    • for garnish paprika

    Instructions

    • Preheat the oven to  425 degrees Fahrenheit (218 degrees Celsius) and grease a 9x13" casserole dish.
    • Heat the oil in a medium skillet over medium high heat.  Generously salt and pepper the chicken breasts on both sides, then cook until cooked through - about 4 - 5 minutes per side.  Remove to a plate and set aside.
    • While the chicken is cooking, heat the water for the pasta and cook for about 1 minute less than package directions.  When cooked, drain in a colander and let sit.
    • Return the pan you cooked the chicken in to medium heat, add two tablespoon of butter and allow to melt.  Add the onion and peppers, and cook until softened, about 4 minutes.
    • Increase the heat to medium high, add the mushrooms and cook until golden brown, about 5 more minutes.
    • In a saucepan, melt the remaining 4 tablespoon butter over medium-low heat.  Whisk in the flour until smooth, then stir in the half and half and the chicken broth.  Increase the heat to medium, and cook and stir until thickened, about 10 minutes, then stir in the white wine and mushrooms.
    • Cube up the cooked chicken, and stir into the sauce.
    • Put the spaghetti noodles into your prepared baking dish, then pour the sauce over the top - shake the dish to even everything out.
    • Sprinkle the parmesan over the top and bake for about 20 minutes, or until hot and bubbly.  Before serving, sprinkle with paprika.

    Video

    Notes

    • Want to add more spices or herbs? Do it. Don't like mushrooms? by all means, exclude them. Want it a bit more buttery and cheesy? Just add more!
    • Want to add more spices or herbs? Do it. Don't like mushrooms? by all means, exclude them. Want it a bit more buttery and cheesy? Just add more!
    • When it comes to white wine, opt for a light-bodied dry white. I prefer oaked chenin blanc, chardonnay, sauvignon blanc or viognier.
    • Always use low-sodium chicken broth. If possible, make your own homemade broth.
    • Undercook the pasta to avoid a mushy baked mess.
    • The sauce shouldn't be too thick or thin. Add more broth, or wine to maintain a nice consistency.

    Nutrition

    Calories: 561kcal | Carbohydrates: 70g | Protein: 33g | Fat: 15g | Saturated Fat: 9g | Trans Fat: 1g | Cholesterol: 70mg | Sodium: 547mg | Potassium: 713mg | Fiber: 3g | Sugar: 4g | Vitamin A: 330IU | Vitamin C: 24mg | Calcium: 190mg | Iron: 2mg

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    Reader Interactions

    Comments

      4.72 from 7 votes (2 ratings without comment)

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      Recipe Rating




    1. D. Lee

      July 27, 2014 at 8:11 am

      This looks delicious - I'm making it with leftover chicken.

      Reply
    2. Janet Stephens McCluskey

      October 20, 2014 at 3:51 pm

      This took me a lot longer than 30 minutes to prep, and seemed to dirty every pot and pan I own. I vowed I would never make it again no matter how good it was. Ahem... that was the first time I made it 🙂 The next three or four times, I figured out how to save a little time and a few dishes and now it is in my monthly rotation. Delicious and worth every step! Thank you for sharing it. My picky twin (13-year old) step-sons loved it as did their father and I, and my mother thoroughly enjoyed the leftovers that I passed on to her.

      Reply
    3. Angie

      December 09, 2014 at 3:56 pm

      I made this today. It was very good! Even a picky 5 year old ate it! Like Fastcook said, it DOES dirty up a WHOLE lot of dishes but if you have a dishwasher and you make sure it's cleared out beforehand, then you can just stick the dishes in the dishwater after you put the dish in the oven for easy cleanup.

      Reply
    4. Vanessa Jones

      February 13, 2015 at 7:18 am

      again, what can I substitute for the wine?

      Reply
    5. ptuplaw

      August 07, 2015 at 3:55 pm

      Oh for heaven's sake! It does NOT make too many dirty dishes. If you are that concerned, use a deep skillet for the chicken and veggies, then place them in the casserole dish to wait and make the sauce in the skillet. You'll use 1 pan, 1 pot, and the casserole dish, which doubles as the serving dish. Really people. As for the number of steps...good food requires a little caring. This turned out very well!

      Reply
    6. Irene

      September 30, 2015 at 2:58 am

      This might seem a bit dumb but I'm from down under n was wondering what is half n half?

      Reply
    7. Ian Bryant

      October 31, 2017 at 7:20 pm

      For me Tetrazzini should have a breadcrumb topping!

      Reply
    8. Kate

      November 02, 2017 at 1:24 pm

      5 stars
      Just made this and we love it. From the age 1 year to 75 years. One a fussy eater and 1 a chef.
      It must be good

      Reply
    9. Carol

      January 28, 2018 at 12:56 am

      Could I use milk instead of half and half

      Reply
    10. Gail Allison

      July 29, 2018 at 8:20 am

      can this be made in the am and than put into the oven for supper to be heated?

      Reply
    11. Carolyn Verone

      September 24, 2018 at 8:44 pm

      5 stars
      Oh yum...such a wonderful flavor...course I put some garlic into the sauce... It does take at least an hour to prepare... Half and half is a must for the creamy sauce...follow all the directions to a savory delicious dinner...

      Reply
    12. Shirley Hildebran

      March 30, 2019 at 5:17 pm

      4 stars
      We enjoyed this dish. I used white cooking wine, since that's what I had. Do leftovers freeze well?

      Reply
    13. Molly Snider

      September 15, 2022 at 3:48 pm

      4 stars
      Love a good casserole! This is right up my alley. I will serve with a salad.

      Reply
    14. Park Avenue

      September 18, 2022 at 4:26 pm

      I'm so happy to see these 1950-'60-70s staple dinners making a comeback. They were the comfort foods of my youth.
      Thank you for this recipe.
      My Mother always added pimentos to her casserole.

      Reply
      • Park Avenue

        September 18, 2022 at 4:28 pm

        5 stars
        I'm so happy to see these 1950-'60-70s staple dinners making a comeback. They were the comfort foods of my youth.
        Thank you for this recipe.
        My Mother always added pimentos to her casserole.

        Reply

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    Chef Ben Rayl

    Hi, I'm Ben!

    I believe comfort food unites us, and I want to inspire you to cook at home with everyday ingredients. It is easier and takes less time than you think, costs less than eating out, and tastes a million times better.Read More

    Feel free to share our recipes on your blog using a photo and link back to the original recipe.

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